RNA-directed RNA polymerase lambda-3
Details
- Name
- RNA-directed RNA polymerase lambda-3
- Kind
- protein
- Synonyms
- 2.7.7.48
- Lambda3
- Lambda3(Pol)
- Gene Name
- L1
- UniProtKB Entry
- P0CK31Swiss-Prot
- Organism
- T3D
- NCBI Taxonomy ID
- 10886
- Amino acid sequence
>lcl|BSEQ0013321|RNA-directed RNA polymerase lambda-3 MSSMILTQFGPFIESISGITDQSNDVFEDAAKAFSMFTRSDVYKALDEIPFSDDAMLPIP PTIYTKPSHDSYYYIDALNRVRRKTYQGPDDVYVPNCSIVELLEPHETLTSYGRLSEAIE NRAKDGDSQARIATTYGRIAESQARQIKAPLEKFVLALLVAEAGGSLYDPVLQKYDEIPD LSHNCPLWCFREICRHISGPLPDRAPYLYLSAGVFWLMSPRMTSAIPPLLSDLVNLAILQ QTAGLDPSLVKLGVQICLHAAASSSYSWFILKTKSIFPQNTLHSMYESLEGGYCPNLEWL EPRSDYKFMYMGVMPLSAKYARSAPSNDKKARELGEKYGLSSVVGELRKRTKTYVKHDFA SVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQKDWTGPIGEIRILKDTTSS IARYLYRTWYLAAARMAAQPRTWDPLFQAIMRSQYVTARGGSGAALRESLYAINVSLPDF KGLPVKAATKIFQAAQLANLPFSHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSA PHTLTADYINYHMNLSPTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLS VIMAAIHEGVASSSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMIQHLSKLYKRGFS YRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETFLTVWGPEHTDDPDVLRLM KSLTIQRNYVCQGDDGLMIIDGTTAGKVNSETIQNDLELISKYGEEFGWKYDIAYDGTAE YLKLYFIFGCRIPNLSRHPIVGKERANSSAEEPWPAILDQIMGVFFNGVHDGLQWQRWIR YSWALCCAFSRQRTMIGESVGYLQYPMWSFVYWGLPLVKAFGSDPWIFSWYMPTGDLGMY SWISLIRPLMTRWMVANGYVTDRCSTVFGNADYRRCFNELKLYQGYYMAQLPRNPKKSGR AASREVREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHNPPSLFDVPHKWYQGA QEAAIATREELAEMDETLMRARRHSYSSFSKLLEAYLLVKWRMCEAREPSVDLRLPLCAG IDPLNSDPFLKMVSVGPMLQSTRKYFAQTLFMAKTVSGLDVNAIDSALLRLRTLGADKKA LTAQLLMVGLQESEADALAGKIMLQDVNTVQLARVVNLAVPDTWMSLDFDSMFKHHVKLL PKDGRHLNTDIPPRMGWLRAILRFLGAGMVMTATGVAVDIYLEDIHGGGRSLGQRFMTWM RQEGRSA
- Number of residues
- 1267
- Molecular Weight
- 142268.83
- Theoretical pI
- 8.02
- GO Classification
- Functionshydrolase activity / nucleotide binding / RNA binding / RNA-directed RNA polymerase activityProcessesviral genome replicationComponentsviral nucleocapsid
- General Function
- RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.
- Specific Function
- hydrolase activity
- Pfam Domain Function
- RdRP_5 (PF07925)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Virion
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0CK31 UniProtKB Entry Name RDRP_REOVD GenBank Protein ID 499864 GenBank Gene ID M24734 PDB ID(s) 1MUK, 1MWH, 1N1H, 1N35, 1N38, 1UON - General References
- Wiener JR, Joklik WK: The sequences of the reovirus serotype 1, 2, and 3 L1 genome segments and analysis of the mode of divergence of the reovirus serotypes. Virology. 1989 Mar;169(1):194-203. [Article]
- Kobayashi T, Antar AA, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS: A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 2007 Apr 19;1(2):147-57. [Article]
- Tao Y, Farsetta DL, Nibert ML, Harrison SC: RNA synthesis in a cage--structural studies of reovirus polymerase lambda3. Cell. 2002 Nov 27;111(5):733-45. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 7-methyl-guanosine-5'-triphosphate-5'-guanosine experimental unknown target Details