Steroid 21-hydroxylase

BE0004873ProteinHumansCYP21A2

A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. It is acted on by 3 drugs in DrugBank.

Gene name
CYP21A2
UniProtKB entry
P08686Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
495 residues · 56,001 Da
Also known as
1.14.14.16 · 21-OHase · CYP21 · CYP21B · Cytochrome P-450c21

Resolves to

Protein
UniProtP08686UniProt nameCP21A_HUMAN
Gene
HGNCHGNC:2600NCBI Gene1589GeneCardsCYP21A2
Pharmacology
IUPHAR/GtoPdb1364KEGGhsa:1589
Structure
PDB4Y8WPDB5VBU
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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88+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Steroid 21-hydroxylase, how selective are they, and which programs against it are still in active trials?

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