Sodium/potassium-transporting ATPase subunit alpha-2

BE0005034ProteinHumansATP1A2

Catalytic subunit of the Na(+)/K(+)-ATPase that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle (PubMed:33880529). It is acted on by 7 drugs in DrugBank.

Gene name
ATP1A2
UniProtKB entry
P50993Swiss-Prot
Cellular location
Membrane
Residues / weight
1,020 residues · 112,264 Da
Also known as
7.2.2.13 · KIAA0778 · Na(+)/K(+) ATPase alpha-2 subunit · Sodium pump subunit alpha-2

Resolves to

Protein
UniProtP50993UniProt nameAT1A2_HUMAN
Gene
HGNCHGNC:800NCBI Gene477GeneCardsATP1A2
Pharmacology
KEGGhsa:477
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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36GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/potassium-transporting ATPase subunit alpha-2, how selective are they, and which programs against it are still in active trials?

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