A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell... It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase.
- Mechanism
- Curator reviewed
Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabain also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
- Primary indication
- For the treatment of atrial fibrillation and flutter and heart failureCurator reviewed
- Formula / weight
- C29H44O12 · 584.6525 g/mol (avg)
- Also known as
- G-Strophanthin · Ouabagenin L-Rhamnoside · Ouabaine · Oubain
Resolves to
LPMXVESGRSUGHW-HBYQJFLCSA-NSMILES[H][C@@]12CC[C@]3(O)C[C@H](C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]1(C)[C@H](CC[C@]21O)C1=CC(=O)OC1)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Ouabain, and which of those have an active Phase 3 trial?
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