Sodium/potassium-transporting ATPase subunit alpha-3

BE0005047ProteinHumansATP1A3

Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:36075933). It is acted on by 7 drugs in DrugBank.

Gene name
ATP1A3
UniProtKB entry
P13637Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,013 residues · 111,748 Da
Also known as
7.2.2.13 · Na(+)/K(+) ATPase alpha-3 subunit · Na(+)/K(+) ATPase alpha(III) subunit · Sodium pump subunit alpha-3

Resolves to

Protein
UniProtP13637UniProt nameAT1A3_HUMAN
Gene
HGNCHGNC:801NCBI Gene478GeneCardsATP1A3
Pharmacology
KEGGhsa:478
Structure
PDB8D3UPDB8D3VPDB8D3W
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/potassium-transporting ATPase subunit alpha-3, how selective are they, and which programs against it are still in active trials?

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