Transient receptor potential cation channel subfamily M member 6

BE0005126ProteinHumansTRPM6

Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain (PubMed:14576148,... It is acted on by 2 drugs in DrugBank.

Gene name
TRPM6
UniProtKB entry
Q9BX84Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,022 residues · 231,706 Da
Also known as
2.7.11.1 · CHAK2 · Channel kinase 2 · Melastatin-related TRP cation channel 6

Resolves to

Protein
UniProtQ9BX84UniProt nameTRPM6_HUMAN
Gene
HGNCHGNC:17995NCBI Gene140803GeneCardsTRPM6
Pharmacology
IUPHAR/GtoPdb498KEGGhsa:140803
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
5Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
10+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Transient receptor potential cation channel subfamily M member 6, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In