Magnesium carbonate
Identification
- Summary
Magnesium carbonate is an antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
- Brand Names
- Acid Gone, Gaviscon, Magnebind 400 Rx, Renacidin
- Generic Name
- Magnesium carbonate
- DrugBank Accession Number
- DB09481
- Background
Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach Label.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Magnesium carbonate (DB09481)
- Weight
- Average: 84.314
Monoisotopic: 83.969785764 - Chemical Formula
- CMgO3
- Synonyms
- Magnesio carbonato
- External IDs
- C.I. 77713
Pharmacology
- Indication
Used as an over the counter antacid 5.
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- Associated Therapies
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Neutralizes acid in the stomach 5.
- Mechanism of action
Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach 5.
Target Actions Organism UGlutamate (NMDA) receptor blockerHumans - Absorption
About 40-60% of magnesium is absorbed following oral administration 5. Percent absorption decreases as dose increases.
- Volume of distribution
Vd for magnesium is 0.2-0.4L/kg 5. About 50% distributes to bone.
- Protein binding
30% of magnesium is bound to proteins 5.
- Metabolism
Magnesium does not appear to be metabolized in any way 5.
- Route of elimination
Primarily eliminated in urine 5.
- Half-life
Half life of 27.7 hours reported with overdose of 400mEq of magnesium in an adult 5.
- Clearance
Maximum magnesium clearance is directly proportional to creatinine clearance 5.
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia 5.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Abacavir may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. Aceclofenac Aceclofenac may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. Acetaminophen Magnesium carbonate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy. Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Magnesium carbonate. Acetophenazine Magnesium carbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy. Aclidinium The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Aclidinium. Acrivastine Magnesium carbonate may decrease the excretion rate of Acrivastine which could result in a higher serum level. Acyclovir Acyclovir may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Magnesium carbonate basic YQO029V1L4 39409-82-0 UOVKYUCEFPSRIJ-UHFFFAOYSA-D - Active Moieties
Name Kind UNII CAS InChI Key Magnesium cation ionic T6V3LHY838 22537-22-0 JLVVSXFLKOJNIY-UHFFFAOYSA-N Carbonate ion ionic 7UJQ5OPE7D 3812-32-6 BVKZGUZCCUSVTD-UHFFFAOYSA-L - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Cepasium Tab 100mg Tablet 100 mg Oral Laboratoires Cortunon Inc. 1979-12-31 2002-08-23 Canada 
Humco Dewees Carminative Suspension 50 mg/1mL Oral Humco Holding Group. Inc. 1998-03-25 Not applicable US 
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Acid Gone Antacid Magnesium carbonate (358 mg/15mL) + Aluminum hydroxide (95 mg/15mL) Liquid Oral Major 2004-12-30 Not applicable US Acid Gone Antacid Extra Strength Magnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1) Tablet, chewable Oral Avera McKennan Hospital 2015-07-09 2017-05-24 US Acid Gone Antacid Extra Strength Magnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1) Tablet, chewable Oral Major Pharmaceuticals 2014-06-06 Not applicable US Aluminum hydroxide and Magnesium carbonate Magnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1) Tablet, chewable Oral Simpex Pharma Pvt. Ltd 2018-02-09 Not applicable US Antacid Magnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1) Tablet, chewable Oral Meijer Distribution 1996-09-05 2016-12-26 US Antacid - Tab Magnesium carbonate (172.2 mg) + Calcium carbonate (327.8 mg) Tablet Oral Swiss Herbal Remedies Ltd. 1996-09-04 2003-09-10 Canada Antacid Extra Strength Magnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1) Tablet, chewable Oral Rite Aid 1997-08-07 2012-08-24 US Aspirin Plus Stomach Guard Ext.stgth.caplet Magnesium carbonate (52.3 mg / tab) + Acetylsalicylic acid (500 mg / tab) + Calcium carbonate (246.2 mg / tab) + Magnesium oxide (96.9 mg / tab) Tablet Oral Sterling Winthrop Inc. 1994-12-31 1996-09-10 Canada Aspirin Plus Stomach Guard Extra Strength Magnesium carbonate (52.32 mg / tab) + Acetylsalicylic acid (500 mg / tab) + Calcium carbonate (246.22 mg / tab) + Magnesium oxide (96.95 mg / tab) Tablet Oral Bayer Inc Consumer Care 1995-12-31 1998-09-28 Canada Aspirin Plus Stomach Guard Tab Magnesium carbonate (34 mg / tab) + Acetylsalicylic acid (325 mg / tab) + Calcium carbonate (160 mg / tab) + Magnesium oxide (63 mg / tab) Tablet Oral Sterling Winthrop Inc. 1994-12-31 1996-09-10 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image MagneBind 400 Rx Magnesium carbonate (115 mg/1) + Calcium carbonate (80 mg/1) + Folic acid (1 mg/1) Tablet, film coated Oral Nephro-Tech, Inc. 1999-10-18 Not applicable US MagneBind 400 Rx Magnesium carbonate (115 mg/1) + Calcium carbonate (80 mg/1) + Folic acid (1 mg/1) Tablet, film coated Oral Carilion Materials Management 1999-10-18 Not applicable US OSVAREN 435 MG/235 MG 180 FILM KAPLI TABLET Magnesium carbonate (235 mg) + Calcium acetate (435 mg) Tablet, coated Oral FRESENIUS MEDİKAL HİZMETLER A.Ş. 2020-08-14 2020-12-09 Turkey 
Categories
- ATC Codes
- A02AA01 — Magnesium carbonate
- A02AA — Magnesium compounds
- A02A — ANTACIDS
- A02 — DRUGS FOR ACID RELATED DISORDERS
- A — ALIMENTARY TRACT AND METABOLISM
- V03AE — Drugs for treatment of hyperkalemia and hyperphosphatemia
- V03A — ALL OTHER THERAPEUTIC PRODUCTS
- V03 — ALL OTHER THERAPEUTIC PRODUCTS
- V — VARIOUS
- Drug Categories
- Agents that produce neuromuscular block (indirect)
- Alimentary Tract and Metabolism
- Aluminum and magnesium containing antacids
- Antacids
- Bleaching Agents
- Calculi Dissolution Agent
- Compounds used in a research, industrial, or household setting
- Drugs for Acid Related Disorders
- Drugs for Constipation
- Drugs for Treatment of Hyperkalemia and Hyperphosphatemia
- Drugs that are Mainly Renally Excreted
- Elements
- Gastric Acid Lowering Agents
- Hygroscopic Agents
- Laxatives
- Laxatives, magnesium containing
- Magnesium Compounds
- Metal cations
- Metal divalent cations
- Metals
- Metals, Alkaline Earth
- Metals, Light
- Noxae
- Osmotic Laxatives
- Oxidants
- Toxic Actions
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Organic carbonic acids and derivatives
- Sub Class
- Organic carbonic acids
- Direct Parent
- Organic carbonic acids
- Alternative Parents
- Carbonate salts / Organic salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Aliphatic acyclic compound / Carbonate salt / Carbonic acid / Carbonyl group / Hydrocarbon derivative / Organic oxide / Organic oxygen compound / Organic salt / Organooxygen compound
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- magnesium salt, one-carbon compound, carbonate salt (CHEBI:31793)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 0IHC698356
- CAS number
- 546-93-0
- InChI Key
- ZLNQQNXFFQJAID-UHFFFAOYSA-L
- InChI
- InChI=1S/CH2O3.Mg/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
- IUPAC Name
- magnesium(2+) ion carbonate
- SMILES
- [Mg++].[O-]C([O-])=O
References
- General References
- de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388. [Article]
- Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [Article]
- Nikolaev MV, Magazanik LG, Tikhonov DB: Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. Neuropharmacology. 2012 Apr;62(5-6):2078-85. doi: 10.1016/j.neuropharm.2011.12.029. Epub 2012 Jan 12. [Article]
- CDC NIOSH: MgCO3 [Link]
- Toxnet [Link]
- External Links
- KEGG Compound
- C12893
- PubChem Compound
- 11029
- PubChem Substance
- 347827861
- ChemSpider
- 10563
- 29155
- ChEBI
- 31793
- ChEMBL
- CHEMBL1200736
- Wikipedia
- Magnesium_carbonate
- FDA label
- Download (129 KB)
- MSDS
- Download (79.7 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Dyspepsia 1 3 Completed Treatment Gastro-esophageal Reflux Disease (GERD) 1 3 Terminated Other Gastro-esophageal Reflux Disease (GERD) 1 2, 3 Completed Treatment Chronic Kidney Disease (CKD) / Hyperphosphataemia 1 1 Completed Basic Science Gastro-esophageal Reflux Disease (GERD) 2 1 Completed Treatment Healthy Subjects (HS) 1 1 Recruiting Treatment Obesity (Disorder) 1 Not Available Completed Diagnostic Gastroesophageal Reflux 1 Not Available Unknown Status Supportive Care Secondary Hyperparathyroidism (SHPT) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Suspension Oral 2.39 g Tablet, effervescent Oral Tablet Oral 100 mg Tablet, chewable Oral Suspension Oral Liquid Oral Solution Oral Suspension Oral 50 mg/1mL Granule Oral Tablet, film coated Oral Powder, for solution Oral Tablet Transmucosal Tablet Oral Granule, for solution Oral Tablet, coated Oral Solution Irrigation Lozenge Oral Capsule Oral Powder Oral Suspension Powder Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) Decomposes at 350 NIOSH [L781] boiling point (°C) Decomposes NIOSH [L781] water solubility 0.1g/L NIOSH [L781] - Predicted Properties
Property Value Source Water Solubility 226.0 mg/mL ALOGPS logP 0.52 ALOGPS logP 0.25 ChemAxon logS 0.21 ALOGPS pKa (Strongest Acidic) 6.05 ChemAxon Physiological Charge -1 ChemAxon Hydrogen Acceptor Count 3 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 63.19 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 31.17 m3·mol-1 ChemAxon Polarizability 3.52 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available
Targets
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- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Blocker
- General Function
- Voltage-gated cation channel activity
- Specific Function
- NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic p...
Components:
References
- Nikolaev MV, Magazanik LG, Tikhonov DB: Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. Neuropharmacology. 2012 Apr;62(5-6):2078-85. doi: 10.1016/j.neuropharm.2011.12.029. Epub 2012 Jan 12. [Article]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Protein serine/threonine kinase activity
- Specific Function
- Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the g...
- Gene Name
- TRPM6
- Uniprot ID
- Q9BX84
- Uniprot Name
- Transient receptor potential cation channel subfamily M member 6
- Molecular Weight
- 231705.935 Da
References
- Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Cation transmembrane transporter activity
- Specific Function
- Not Available
- Gene Name
- SLC41A3
- Uniprot ID
- Q96GZ6
- Uniprot Name
- Solute carrier family 41 member 3
- Molecular Weight
- 54766.1 Da
References
- de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Magnesium ion transmembrane transporter activity
- Specific Function
- Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
- Gene Name
- CNNM2
- Uniprot ID
- Q9H8M5
- Uniprot Name
- Metal transporter CNNM2
- Molecular Weight
- 96622.35 Da
References
- de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Protein serine/threonine kinase activity
- Specific Function
- Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxi...
- Gene Name
- TRPM7
- Uniprot ID
- Q96QT4
- Uniprot Name
- Transient receptor potential cation channel subfamily M member 7
- Molecular Weight
- 212695.37 Da
References
- Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [Article]
Drug created on November 30, 2015 19:10 / Updated on December 11, 2020 21:57