Magnesium carbonate

Identification

Summary

Magnesium carbonate is an antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.

Brand Names
Acid Gone, Gaviscon, Magnebind 400 Rx, Renacidin
Generic Name
Magnesium carbonate
DrugBank Accession Number
DB09481
Background

Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach Label.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 84.314
Monoisotopic: 83.969785764
Chemical Formula
CMgO3
Synonyms
  • Magnesio carbonato
External IDs
  • C.I. 77713

Pharmacology

Indication

Used as an over the counter antacid 5.

Pharmacology
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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Neutralizes acid in the stomach 5.

Mechanism of action

Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach 5.

TargetActionsOrganism
UGlutamate (NMDA) receptor
blocker
Humans
Absorption

About 40-60% of magnesium is absorbed following oral administration 5. Percent absorption decreases as dose increases.

Volume of distribution

Vd for magnesium is 0.2-0.4L/kg 5. About 50% distributes to bone.

Protein binding

30% of magnesium is bound to proteins 5.

Metabolism

Magnesium does not appear to be metabolized in any way 5.

Route of elimination

Primarily eliminated in urine 5.

Half-life

Half life of 27.7 hours reported with overdose of 400mEq of magnesium in an adult 5.

Clearance

Maximum magnesium clearance is directly proportional to creatinine clearance 5.

Adverse Effects
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Toxicity

During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia 5.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
AcetaminophenMagnesium carbonate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Magnesium carbonate.
AcetophenazineMagnesium carbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
AclidiniumAclidinium may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
AcrivastineMagnesium carbonate may decrease the excretion rate of Acrivastine which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
Adefovir dipivoxilAdefovir dipivoxil may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
Interactions
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Food Interactions
No interactions found.

Products

Products
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Product Ingredients
IngredientUNIICASInChI Key
Magnesium carbonate basicYQO029V1L439409-82-0UOVKYUCEFPSRIJ-UHFFFAOYSA-D
Active Moieties
NameKindUNIICASInChI Key
Magnesium cationionicT6V3LHY83822537-22-0JLVVSXFLKOJNIY-UHFFFAOYSA-N
Carbonate ionionic7UJQ5OPE7D3812-32-6BVKZGUZCCUSVTD-UHFFFAOYSA-L
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Cepasium Tab 100mgTablet100 mgOralLaboratoires Cortunon Inc.1979-12-312002-08-23Canada flag
Humco Dewees CarminativeSuspension50 mg/1mLOralHumco Holding Group. Inc.1998-03-25Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Acid Gone AntacidMagnesium carbonate (358 mg/15mL) + Aluminum hydroxide (95 mg/15mL)LiquidOralMajor2004-12-30Not applicableUS flag
Acid Gone Antacid Extra StrengthMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralMajor Pharmaceuticals2014-06-06Not applicableUS flag
Acid Gone Antacid Extra StrengthMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralAvera McKennan Hospital2015-07-092017-05-24US flag
Aluminum hydroxide and Magnesium carbonateMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralSimpex Pharma Pvt. Ltd2018-02-09Not applicableUS flag
AntacidMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralMeijer Distribution1996-09-052016-12-26US flag
Antacid - TabMagnesium carbonate (172.2 mg) + Calcium carbonate (327.8 mg)TabletOralSwiss Herbal Remedies Ltd.1996-09-042003-09-10Canada flag
Antacid Extra StrengthMagnesium carbonate (105 mg/1) + Aluminum hydroxide (160 mg/1)Tablet, chewableOralRite Aid1997-08-072012-08-24US flag
Aspirin Plus Stomach Guard Ext.stgth.capletMagnesium carbonate (52.3 mg / tab) + Acetylsalicylic acid (500 mg / tab) + Calcium carbonate (246.2 mg / tab) + Magnesium oxide (96.9 mg / tab)TabletOralSterling Winthrop Inc.1994-12-311996-09-10Canada flag
Aspirin Plus Stomach Guard Extra StrengthMagnesium carbonate (52.32 mg / tab) + Acetylsalicylic acid (500 mg / tab) + Calcium carbonate (246.22 mg / tab) + Magnesium oxide (96.95 mg / tab)TabletOralBayer Inc Consumer Care1995-12-311998-09-28Canada flag
Aspirin Plus Stomach Guard TabMagnesium carbonate (34 mg / tab) + Acetylsalicylic acid (325 mg / tab) + Calcium carbonate (160 mg / tab) + Magnesium oxide (63 mg / tab)TabletOralSterling Winthrop Inc.1994-12-311996-09-10Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
MagneBind 400 RxMagnesium carbonate (115 mg/1) + Calcium carbonate (80 mg/1) + Folic acid (1 mg/1)Tablet, film coatedOralCarilion Materials Management1999-10-18Not applicableUS flag
MagneBind 400 RxMagnesium carbonate (115 mg/1) + Calcium carbonate (80 mg/1) + Folic acid (1 mg/1)Tablet, film coatedOralNephro-Tech, Inc.1999-10-18Not applicableUS flag
OSVAREN 435 MG/235 MG 180 FILM KAPLI TABLETMagnesium carbonate (235 mg) + Calcium acetate (435 mg)Tablet, coatedOralFRESENIUS MEDİKAL HİZMETLER A.Ş.2020-08-142020-12-09Turkey flag

Categories

ATC Codes
A02AA01 — Magnesium carbonateV03AE04 — Calcium acetate and magnesium carbonateA06AD01 — Magnesium carbonate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as organic carbonic acids. These are compounds comprising the carbonic acid functional group.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Organic carbonic acids and derivatives
Sub Class
Organic carbonic acids
Direct Parent
Organic carbonic acids
Alternative Parents
Carbonate salts / Organic salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Aliphatic acyclic compound / Carbonate salt / Carbonic acid / Carbonyl group / Hydrocarbon derivative / Organic oxide / Organic oxygen compound / Organic salt / Organooxygen compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
magnesium salt, one-carbon compound, carbonate salt (CHEBI:31793)
Affected organisms
Not Available

Chemical Identifiers

UNII
0IHC698356
CAS number
546-93-0
InChI Key
ZLNQQNXFFQJAID-UHFFFAOYSA-L
InChI
InChI=1S/CH2O3.Mg/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
IUPAC Name
magnesium(2+) ion carbonate
SMILES
[Mg++].[O-]C([O-])=O

References

General References
  1. de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388. [Article]
  2. Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [Article]
  3. Nikolaev MV, Magazanik LG, Tikhonov DB: Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. Neuropharmacology. 2012 Apr;62(5-6):2078-85. doi: 10.1016/j.neuropharm.2011.12.029. Epub 2012 Jan 12. [Article]
  4. CDC NIOSH: MgCO3 [Link]
  5. Toxnet [Link]
KEGG Compound
C12893
PubChem Compound
11029
PubChem Substance
347827861
ChemSpider
10563
RxNav
29155
ChEBI
31793
ChEMBL
CHEMBL1200736
Wikipedia
Magnesium_carbonate
FDA label
Download (129 KB)
MSDS
Download (79.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentDyspepsia1
3CompletedTreatmentGastro-esophageal Reflux Disease (GERD)1
3TerminatedOtherGastro-esophageal Reflux Disease (GERD)1
2, 3CompletedTreatmentChronic Kidney Disease (CKD) / Hyperphosphataemia1
1CompletedBasic ScienceGastro-esophageal Reflux Disease (GERD)2
1CompletedTreatmentHealthy Volunteers1
Not AvailableCompletedDiagnosticGastroesophageal Reflux1
Not AvailableUnknown StatusSupportive CareSecondary Hyperparathyroidism (SHPT)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, effervescentOral
TabletOral100 mg
Powder, for solutionOral
PowderOral
SuspensionOral
LiquidOral
SolutionOral
SuspensionOral50 mg/1mL
GranuleOral
Tablet, film coatedOral
TabletTransmucosal
Granule, for solutionOral
TabletOral
Tablet, coatedOral
SolutionIrrigation
LozengeOral
Tablet, chewableOral
CapsuleOral
Suspension
Powder
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)Decomposes at 350NIOSH [L781]
boiling point (°C)DecomposesNIOSH [L781]
water solubility0.1g/LNIOSH [L781]
Predicted Properties
PropertyValueSource
Water Solubility226.0 mg/mLALOGPS
logP0.52ALOGPS
logP0.25ChemAxon
logS0.21ALOGPS
pKa (Strongest Acidic)6.05ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area63.19 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity31.17 m3·mol-1ChemAxon
Polarizability3.52 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Targets

Drugtargets
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Kind
Protein group
Organism
Humans
Pharmacological action
Unknown
Actions
Blocker
General Function
Voltage-gated cation channel activity
Specific Function
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic p...

Components:
References
  1. Nikolaev MV, Magazanik LG, Tikhonov DB: Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. Neuropharmacology. 2012 Apr;62(5-6):2078-85. doi: 10.1016/j.neuropharm.2011.12.029. Epub 2012 Jan 12. [Article]

Transporters

Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Protein serine/threonine kinase activity
Specific Function
Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the g...
Gene Name
TRPM6
Uniprot ID
Q9BX84
Uniprot Name
Transient receptor potential cation channel subfamily M member 6
Molecular Weight
231705.935 Da
References
  1. Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Cation transmembrane transporter activity
Specific Function
Not Available
Gene Name
SLC41A3
Uniprot ID
Q96GZ6
Uniprot Name
Solute carrier family 41 member 3
Molecular Weight
54766.1 Da
References
  1. de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Magnesium ion transmembrane transporter activity
Specific Function
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
Gene Name
CNNM2
Uniprot ID
Q9H8M5
Uniprot Name
Metal transporter CNNM2
Molecular Weight
96622.35 Da
References
  1. de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Protein serine/threonine kinase activity
Specific Function
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxi...
Gene Name
TRPM7
Uniprot ID
Q96QT4
Uniprot Name
Transient receptor potential cation channel subfamily M member 7
Molecular Weight
212695.37 Da
References
  1. Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [Article]

Drug created on November 30, 2015 19:10 / Updated on December 11, 2020 21:57