Solute carrier family 2, facilitated glucose transporter member 7

Details

Name

Solute carrier family 2, facilitated glucose transporter member 7

Kind

protein

Synonyms

• Glucose transporter type 7
• GLUT-7
• GLUT7
• hGLUT7

Gene Name

SLC2A7

UniProtKB Entry

Q6PXP3Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0019707|Solute carrier family 2, facilitated glucose transporter member 7
MENKEAGTPPPIPSREGRLQPTLLLATLSAAFGSAFQYGYNLSVVNTPHKVFKSFYNETY
FERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGLLVDSCGRKGTLLINNIFAIIPAI
LMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGV
FLAQIFSLQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQAL
RRLRGHTDMEAELEDMRAEARAERAEGHLSVLHLCALRSLRWQLLSIIVLMAGQQLSGIN
AINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGYGICGS
ACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMV
DGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEINRI
FAKRNRVKLPEEKEETIDAGPPTASPAKETSF

Number of residues

512

Molecular Weight

55726.915

Theoretical pI

Not Available

GO Classification

Functions

D-glucose transmembrane transporter activity / fructose transmembrane transporter activity / hexose transmembrane transporter activity / sugar transmembrane transporter activity

Processes

fructose transmembrane transport / glucose transmembrane transport / hexose transmembrane transport / monosaccharide transmembrane transport

Components

apical plasma membrane

General Function

Probable sugar transporter (PubMed:28083649). Even if its physiological substrate is subject to discussion, it is able to transport glucose and fructose (PubMed:16186102, PubMed:28083649, PubMed:29548810). Does not transport galactose, 2-deoxy-d-glucose and xylose (PubMed:15033637)

Specific Function

D-glucose transmembrane transporter activity

Pfam Domain Function

• Sugar_tr (PF00083)

Signal Regions

Not Available

Transmembrane Regions

22-42 79-99 108-128 139-159 173-193 199-219 282-302 322-342 351-371 380-400 416-436 446-466

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0019708|Solute carrier family 2, facilitated glucose transporter member 7 (SLC2A7)
ATGGAGAACAAAGAGGCGGGAACCCCTCCACCCATTCCATCCAGGGAGGGGCGGCTCCAG
CCGACGCTGTTGCTGGCGACACTGAGCGCGGCCTTTGGCTCAGCCTTCCAGTACGGCTAC
AACCTCTCTGTGGTCAACACGCCGCACAAGGTCTTCAAGTCATTTTACAACGAAACCTAC
TTTGAGCGACACGCAACATTCATGGACGGGAAGCTCATGCTGCTTCTATGGTCTTGCACC
GTCTCCATGTTTCCTCTGGGCGGCCTGTTGGGGTCATTGCTCGTGGGCCTGCTGGTTGAT
AGCTGCGGCAGAAAGGGGACCCTGCTGATCAACAACATCTTTGCCATCATCCCCGCCATC
CTGATGGGAGTCAGCAAAGTGGCCAAGGCTTTTGAGCTGATCGTCTTTTCCCGAGTGGTG
CTGGGAGTCTGTGCAGGCATCTCCTACAGCGCCCTTCCCATGTACCTGGGAGAACTGGCC
CCCAAGAACCTGAGAGGCATGGTGGGAACAATGACCGAGGTTTTCGTCATCGTTGGAGTC
TTCCTAGCACAGATCTTCAGCCTCCAGGCCATCTTGGGCAACCCGGCAGGCTGGCCGGTG
CTTCTGGCGCTCACAGGGGTGCCCGCCCTGCTGCAGCTGCTGACCCTGCCCTTCTTCCCC
GAAAGCCCCCGCTACTCCCTGATTCAGAAAGGAGATGAAGCCACAGCGCGACAAGCTCTG
AGGAGGCTGAGAGGCCACACGGACATGGAGGCCGAGCTGGAGGACATGCGTGCGGAGGCC
CGGGCCGAGCGCGCCGAGGGCCACCTGTCTGTGCTGCACCTCTGTGCCCTGCGGTCCCTG
CGCTGGCAGCTCCTCTCCATCATCGTGCTCATGGCCGGCCAGCAGCTGTCGGGCATCAAT
GCGATCAACTACTATGCGGACACCATCTACACATCTGCGGGCGTGGAGGCCGCTCACTCC
CAATATGTAACGGTGGGCTCTGGCGTCGTCAACATAGTGATGACCATCACCTCGGCTGTC
CTTGTGGAGCGGCTGGGACGGCGGCACCTCCTGCTGGCCGGCTACGGCATCTGCGGCTCT
GCCTGCCTGGTGCTGACGGTGGTGCTCCTATTCCAGAACAGGGTCCCCGAGCTGTCCTAC
CTCGGCATCATCTGTGTCTTTGCCTACATCGCGGGACATTCCATTGGGCCCAGTCCTGTC
CCCTCGGTGGTGAGGACCGAGATCTTCCTGCAGTCCTCCCGGCGGGCAGCTTTCATGGTG
GACGGGGCAGTGCACTGGCTCACCAACTTCATCATAGGCTTCCTGTTCCCATCCATCCAG
GAGGCCATCGGTGCCTACAGTTTCATCATCTTTGCCGGAATCTGCCTCCTCACTGCGATT
TACATCTACGTGGTTATTCCGGAGACCAAGGGCAAAACATTTGTGGAGATAAACCGCATT
TTTGCCAAGAGAAACAGGGTGAAGCTTCCAGAGGAGAAAGAAGAAACCATTGATGCTGGG
CCTCCCACAGCCTCTCCTGCCAAGGAAACTTCCTTTTAG

Chromosome Location

1

Locus

1p36.23

External Identifiers

Resource	Link
UniProtKB ID	Q6PXP3
UniProtKB Entry Name	GTR7_HUMAN
GeneCard ID	SLC2A7
HGNC ID	HGNC:13445
KEGG ID	hsa:155184
NCBI Gene ID	155184

General References

1. Li Q, Manolescu A, Ritzel M, Yao S, Slugoski M, Young JD, Chen XZ, Cheeseman CI: Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine. Am J Physiol Gastrointest Liver Physiol. 2004 Jul;287(1):G236-42. Epub 2004 Mar 19. [Article]
2. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [Article]

Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Fludeoxyglucose (18F)	approved, investigational	no	transporter	substrate	Details
Dextrose, unspecified form	approved, vet_approved	unknown	transporter	substrate	Details
D-glucose	approved, investigational, vet_approved	no	transporter	substrate	Details