Solute carrier family 2, facilitated glucose transporter member 8
Details
- Name
- Solute carrier family 2, facilitated glucose transporter member 8
- Kind
- protein
- Synonyms
- Glucose transporter type 8
- Glucose transporter type X1
- GLUT-8
- GLUT8
- GLUTX1
- Gene Name
- SLC2A8
- UniProtKB Entry
- Q9NY64Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0013546|Solute carrier family 2, facilitated glucose transporter member 8 MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPP APRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDV WMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLE WRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAE QSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGV IQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVS AQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLM AFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR
- Number of residues
- 477
- Molecular Weight
- 50818.54
- Theoretical pI
- Not Available
- GO Classification
- FunctionsD-glucose binding / D-glucose transmembrane transporter activity / dehydroascorbic acid transmembrane transporter activity / fructose transmembrane transporter activityProcessesdehydroascorbic acid transport / fructose transmembrane transport / hexose transmembrane transportComponentsclathrin-coated endocytic vesicle membrane / membrane
- General Function
- Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate
- Specific Function
- D-glucose binding
- Pfam Domain Function
- Sugar_tr (PF00083)
- Signal Regions
- Not Available
- Transmembrane Regions
- 26-46 71-91 97-117 128-148 157-177 183-203 257-277 293-313 320-340 368-388 405-425 439-459
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0013547|Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) ATGACGCCCGAGGACCCAGAGGAAACCCAGCCGCTTCTGGGGCCTCCTGGCGGCAGCGCG CCCCGCGGCCGCCGCGTCTTCCTCGCCGCCTTCGCCGCTGCCCTGGGCCCACTCAGCTTC GGCTTCGCGCTCGGCTACAGCTCCCCGGCCATCCCTAGCCTGCAGCGCGCCGCGCCCCCG GCCCCGCGCCTGGACGACGCCGCCGCCTCCTGGTTCGGGGCTGTCGTGACCCTGGGTGCC GCGGCGGGGGGAGTGCTGGGCGGCTGGCTGGTGGACCGCGCCGGGCGCAAGCTGAGCCTC TTGCTGTGCTCCGTGCCCTTCGTGGCCGGCTTTGCCGTCATCACCGCGGCCCAGGACGTG TGGATGCTGCTGGGGGGCCGCCTCCTCACCGGCCTGGCCTGCGGTGTTGCCTCCCTAGTG GCCCCGGTCTACATCTCCGAAATCGCCTACCCAGCAGTCCGGGGGTTGCTCGGCTCCTGT GTGCAGCTAATGGTCGTCGTCGGCATCCTCCTGGCCTACCTGGCAGGCTGGGTGCTGGAG TGGCGCTGGCTGGCTGTGCTGGGCTGCGTGCCCCCCTCCCTCATGCTGCTTCTCATGTGC TTCATGCCCGAGACCCCGCGCTTCCTGCTGACTCAGCACAGGCGCCAGGAGGCCATGGCC GCCCTGCGGTTCCTGTGGGGCTCCGAGCAGGGCTGGGAAGACCCCCCCATCGGGGCTGAG CAGAGCTTTCACCTGGCCCTGCTGCGGCAGCCCGGCATCTACAAGCCCTTCATCATCGGC GTCTCCCTGATGGCCTTCCAGCAGCTGTCGGGGGTCAACGCCGTCATGTTCTATGCAGAG ACCATCTTTGAAGAGGCCAAGTTCAAGGACAGCAGCCTGGCCTCGGTCGTCGTGGGTGTC ATCCAGGTGCTGTTCACAGCTGTGGCGGCTCTCATCATGGACAGAGCAGGGCGGAGGCTG CTCCTGGTCTTGTCAGGTGTGGTCATGGTGTTCAGCACGAGTGCCTTCGGCGCCTACTTC AAGCTGACCCAGGGTGGCCCTGGCAACTCCTCGCACGTGGCCATCTCGGCGCCTGTCTCT GCACAGCCTGTTGATGCCAGCGTGGGGCTGGCCTGGCTGGCCGTGGGCAGCATGTGCCTC TTCATCGCCGGAGGTCCTCAGGCCCTATGGAGCCTTCTGGCTTGCCTCCGCTTTCTGCAT CTTCAGTGTCCTTTTCACTTTGTTCTGTGTCCCTGA
- Chromosome Location
- 9
- Locus
- 9q33.3
- External Identifiers
Resource Link UniProtKB ID Q9NY64 UniProtKB Entry Name SL2A8_HUMAN GeneCard ID SLC2A8 HGNC ID HGNC:13812 KEGG ID hsa:29988 NCBI Gene ID 29988 - General References
- Doege H, Schurmann A, Bahrenberg G, Brauers A, Joost HG: GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. J Biol Chem. 2000 May 26;275(21):16275-80. [Article]
- Ibberson M, Uldry M, Thorens B: GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem. 2000 Feb 18;275(7):4607-12. [Article]
- Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Fludeoxyglucose (18F) approved, investigational no transporter substrate Details Dextrose, unspecified form approved, vet_approved unknown transporter substrate Details D-glucose approved, investigational, vet_approved no transporter substrate Details