Solute carrier family 2, facilitated glucose transporter member 11

Details

Name

Solute carrier family 2, facilitated glucose transporter member 11

Kind

protein

Synonyms

• Glucose transporter type 11
• GLUT-11
• GLUT11

Gene Name

SLC2A11

UniProtKB Entry

Q9BYW1Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0008985|Solute carrier family 2, facilitated glucose transporter member 11
MRALRRLIQGRILLLTICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPD
HLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGS
FEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRE
LLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLA
GELEELEEERAACQGCRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVF
RKAGVPEAKIQYAIIGTGSCELLTAVVSCVVIERVGRRVLLIGGYSLMTCWGSIFTVALC
LQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLI
LVGLGFPFIMEALSHFLYVPFLGVCVCGAIYTGLFLPETKGKTFQEISKELHRLNFPRRA
QGPTWRSLEVIQSTEL

Number of residues

496

Molecular Weight

53702.055

Theoretical pI

Not Available

GO Classification

Functions

fructose transmembrane transporter activity / glucose transmembrane transporter activity / hexose transmembrane transporter activity / sugar transmembrane transporter activity

Processes

fructose transmembrane transport / glucose transmembrane transport / hexose transmembrane transport / monosaccharide transmembrane transport

Components

nucleoplasm

General Function

Facilitative glucose transporter

Specific Function

fructose transmembrane transporter activity

Pfam Domain Function

• Sugar_tr (PF00083)

Signal Regions

Not Available

Transmembrane Regions

12-32 62-82 98-118 129-149 158-178 188-208 274-294 312-332 339-359 365-385 409-429 436-456

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0013548|Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11)
ATGAGAGCGCTCCGAAGACTGATTCAGGGCAGGATCCTGCTCCTGACCATCTGCGCTGCC
GGCATTGGTGGGACTTTTCAGTTTGGCTATAACCTCTCTATCATCAATGCCCCGACCTTG
CACATTCAGGAATTCACCAATGAGACATGGCAGGCGCGTACTGGAGAGCCACTGCCCGAT
CACCTAGTCCTGCTTATGTGGTCCCTCATCGTGTCTCTGTATCCCCTGGGAGGCCTCTTT
GGAGCACTGCTTGCAGGTCCCTTGGCCATCACGCTGGGAAGGAAGAAGTCCCTCCTGGTG
AATAACATCTTTGTGGTGTCAGCAGCAATCCTGTTTGGATTCAGCCGCAAAGCAGGCTCC
TTTGAGATGATCATGCTGGGAAGACTGCTCGTGGGAGTCAATGCAGGTGTGAGCATGAAC
ATCCAGCCCATGTACCTGGGGGAGAGCGCCCCTAAGGAGCTCCGAGGAGCTGTGGCCATG
AGCTCAGCCATCTTTACGGCTCTGGGGATCGTGATGGGACAGGTGGTCGGACTCAGGGAG
CTCCTAGGTGGCCCTCAGGCCTGGCCCCTGCTGCTGGCCAGCTGCCTGGTGCCCGGGGCG
CTCCAGCTCGCCTCCCTGCCTCTGCTCCCTGAAAGCCCGCGCTACCTCCTCATTGACTGT
GGAGACACCGAGGCCTGCCTGGCAGCACTACGGCGGCTCCGGGGCTCCGGGGACTTGGCA
GGGGAGCTGGAGGAGCTGGAGGAGGAGCGCGCTGCCTGCCAGGGCTGCCGTGCCCGGCGC
CCATGGGAGCTGTTCCAGCATCGGGCCCTGAGGAGACAGGTGACAAGCCTCGTGGTTCTG
GGCAGTGCCATGGAGCTCTGCGGGAATGACTCGGTGTACGCCTACGCCTCCTCCGTGTTC
CGGAAGGCAGGAGTGCCGGAAGCGAAGATCCAGTACGCGATCATCGGGACTGGGAGCTGC
GAGCTGCTCACGGCGGTTGTTAGTTGTGTGGTAATCGAGAGGGTGGGTCGGCGCGTGCTG
CTCATCGGTGGGTACAGCCTGATGACCTGCTGGGGGAGCATCTTCACTGTGGCCCTGTGC
CTGCAGAGCTCCTTCCCCTGGACACTCTACCTGGCCATGGCCTGCATCTTTGCCTTCATC
CTCAGCTTTGGCATTGGCCCTGCCGGAGTGACGGGGATCCTGGCCACAGAGCTGTTTGAC
CAGATGGCCAGGCCTGCTGCCTGCATGGTCTGCGGGGCGCTCATGTGGATCATGCTCATC
CTGGTCGGCCTGGGATTTCCCTTTATCATGGAGGCCTTGTCCCACTTCCTCTATGTCCCT
TTCCTTGGTGTCTGTGTCTGTGGGGCCATCTACACTGGCCTGTTCCTTCCTGAGACCAAA
GGCAAGACCTTCCAAGAGATCTCCAAGGAATTACACAGACTCAACTTCCCCAGGCGGGCC
CAGGGCCCCACGTGGAGGAGCCTGGAGGTTATCCAGTCAACAGAACTCTAG

Chromosome Location

22

Locus

22q11.23

External Identifiers

Resource	Link
UniProtKB ID	Q9BYW1
UniProtKB Entry Name	GTR11_HUMAN
GeneCard ID	SLC2A11
HGNC ID	HGNC:14239
KEGG ID	hsa:66035
NCBI Gene ID	66035

General References

1. Sasaki T, Minoshima S, Shiohama A, Shintani A, Shimizu A, Asakawa S, Kawasaki K, Shimizu N: Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. Biochem Biophys Res Commun. 2001 Dec 21;289(5):1218-24. [Article]
2. Wu X, Li W, Sharma V, Godzik A, Freeze HH: Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Mol Genet Metab. 2002 May;76(1):37-45. [Article]
3. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [Article]
4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
5. Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. 2005;12(2):117-26. [Article]
6. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [Article]
7. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Fludeoxyglucose (18F)	approved, investigational	no	transporter	substrate	Details
Dextrose, unspecified form	approved, vet_approved	unknown	transporter	substrate	Details
D-glucose	approved, investigational, vet_approved	no	transporter	substrate	Details