G protein-coupled bile acid receptor 1

BE0005788ProteinHumansGPBAR1

G protein-coupled receptor for bile acid (PubMed:12419312, PubMed:12524422, PubMed:32698187, PubMed:32747649, PubMed:35858343). It is acted on by 4 drugs in DrugBank.

Gene name
GPBAR1
UniProtKB entry
Q8TDU6Swiss-Prot
Cellular location
Cell membrane
Residues / weight
330 residues · 35,248 Da
Also known as
BG37 · G protein-coupled receptor GPCR19 · hBG37 · hGPCR19 · M-BAR

Resolves to

Protein
UniProtQ8TDU6UniProt nameGPBAR_HUMAN
Gene
HGNCHGNC:19680NCBI Gene151306GeneCardsGPBAR1
Pharmacology
IUPHAR/GtoPdb37KEGGhsa:151306
Structure
PDB7BW0PDB7CFMPDB7CFN
Drugs

What you can answer from here — as of June 19, 2026

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on G protein-coupled bile acid receptor 1, how selective are they, and which programs against it are still in active trials?

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