Endonuclease 8-like 2

BE0005817ProteinHumansNEIL2

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. It is acted on by 7 drugs in DrugBank.

Gene name
NEIL2
UniProtKB entry
Q969S2Swiss-Prot
Cellular location
Nucleus
Residues / weight
332 residues · 36,826 Da
Also known as
3.2.2.- · 4.2.99.18 · DNA glycosylase/AP lyase Neil2 · DNA-(apurinic or apyrimidinic site) lyase Neil2 · Endonuclease VIII-like 2

Resolves to

Protein
UniProtQ969S2UniProt nameNEIL2_HUMAN
Gene
HGNCHGNC:18956NCBI Gene252969GeneCardsNEIL2
Pharmacology
KEGGhsa:252969
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Endonuclease 8-like 2, how selective are they, and which programs against it are still in active trials?

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