Fibroblast growth factor 19

BE0005820ProteinHumansFGF19

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. It is acted on by 2 drugs in DrugBank.

Gene name
FGF19
UniProtKB entry
O95750Swiss-Prot
Cellular location
Secreted
Residues / weight
216 residues · 24,002 Da
Also known as
FGF-19

Resolves to

Protein
UniProtO95750UniProt nameFGF19_HUMAN
Gene
HGNCHGNC:3675NCBI Gene9965GeneCardsFGF19
Pharmacology
KEGGhsa:9965
Structure
PDB1PWAPDB2P23PDB6KTR
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
16+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Fibroblast growth factor 19, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In