Peroxiredoxin-1

BE0005844ProteinHumansPRDX1

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. It is acted on by 7 drugs in DrugBank.

Gene name
PRDX1
UniProtKB entry
Q06830Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
199 residues · 22,110 Da
Also known as
1.11.1.24 · Natural killer cell-enhancing factor A · NKEF-A · PAG · PAGA

Resolves to

Protein
UniProtQ06830UniProt namePRDX1_HUMAN
Gene
HGNCHGNC:9352NCBI Gene5052GeneCardsPRDX1
Pharmacology
KEGGhsa:5052
Structure
PDB2RIIPDB3HY2PDB4XCS
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peroxiredoxin-1, how selective are they, and which programs against it are still in active trials?

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