Orexin/Hypocretin receptor type 1

Details

Name
Orexin/Hypocretin receptor type 1
Kind
protein
Synonyms
  • Hypocretin receptor type 1
  • Orexin receptor type 1
  • Ox-1-R
  • Ox1-R
  • Ox1R
Gene Name
HCRTR1
UniProtKB Entry
O43613Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0019820|Orexin/Hypocretin receptor type 1
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
Number of residues
425
Molecular Weight
47535.33
Theoretical pI
Not Available
GO Classification
Functions
G protein-coupled receptor activity
Processes
chemical synaptic transmission / positive regulation of ERK1 and ERK2 cascade / regulation of cytosolic calcium ion concentration
Components
synapse
General Function
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:26950369, PubMed:9491897). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:26950369, PubMed:9491897)
Specific Function
G protein-coupled receptor activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
47-67 83-105 120-140 161-182 214-235 299-321 337-360
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0019821|Orexin receptor type 1 (HCRTR1)
ATGGAGCCCTCAGCCACCCCAGGGGCCCAGATGGGGGTCCCCCCTGGCAGCAGAGAGCCG
TCCCCTGTGCCTCCAGACTATGAAGATGAGTTTCTCCGCTATCTGTGGCGCGATTATCTG
TACCCAAAACAGTATGAGTGGGTCCTCATCGCAGCCTATGTGGCTGTGTTCGTCGTGGCC
CTGGTGGGCAACACGCTGGTCTGCCTGGCCGTGTGGCGGAACCACCACATGAGGACAGTC
ACCAACTACTTCATTGTCAACCTGTCCCTGGCTGACGTTCTGGTGACTGCTATCTGCCTG
CCGGCCAGCCTGCTGGTGGACATCACTGAGTCCTGGCTGTTCGGCCATGCCCTCTGCAAG
GTCATCCCCTATCTACAGGCTGTGTCCGTGTCAGTGGCAGTGCTAACTCTCAGCTTCATC
GCCCTGGACCGCTGGTATGCCATCTGCCACCCACTATTGTTCAAGAGCACAGCCCGGCGG
GCCCGTGGCTCCATCCTGGGCATCTGGGCTGTGTCGCTGGCCATCATGGTGCCCCAGGCT
GCAGTCATGGAATGCAGCAGTGTGCTGCCTGAGCTAGCCAACCGCACACGGCTCTTCTCA
GTCTGTGATGAACGCTGGGCAGATGACCTCTATCCCAAGATCTACCACAGTTGCTTCTTT
ATTGTCACCTACCTGGCCCCACTGGGCCTCATGGCCATGGCCTATTTCCAGATATTCCGC
AAGCTCTGGGGCCGCCAGATCCCCGGCACCACCTCAGCACTGGTGCGGAACTGGAAGCGC
CCCTCAGACCAGCTGGGGGACCTGGAGCAGGGCCTGAGTGGAGAGCCCCAGCCCCGGGCC
CGCGCCTTCCTGGCTGAAGTGAAGCAGATGCGTGCACGGAGGAAGACAGCCAAGATGCTG
ATGGTGGTGCTGCTGGTCTTCGCCCTCTGCTACCTGCCCATCAGCGTCCTCAATGTCCTT
AAGAGGGTGTTCGGGATGTTCCGCCAAGCCAGTGACCGCGAAGCTGTCTACGCCTGCTTC
ACCTTCTCCCACTGGCTGGTGTACGCCAACAGCGCTGCCAACCCCATCATCTACAACTTC
CTCAGTGGCAAATTCCGGGAGCAGTTTAAGGCTGCCTTCTCCTGCTGCCTGCCTGGCCTG
GGTCCCTGCGGCTCTCTGAAGGCCCCTAGTCCCCGCTCCTCTGCCAGCCACAAGTCCTTG
TCCTTGCAGAGCCGATGCTCCATCTCCAAAATCTCTGAGCATGTGGTGCTCACCAGCGTC
ACCACAGTGCTGCCCTGA
Chromosome Location
1
Locus
1p35.2
External Identifiers
ResourceLink
UniProtKB IDO43613
UniProtKB Entry NameOX1R_HUMAN
GeneCard IDHCRTR1
HGNC IDHGNC:4848
PDB ID(s)4ZJ8, 4ZJC, 6TO7, 6TOD, 6TOS, 6TOT, 6TP3, 6TP4, 6TP6, 6TQ4, 6TQ6, 6TQ7, 6TQ9, 6V9S
KEGG IDhsa:3061
IUPHAR/Guide To Pharmacology ID321
NCBI Gene ID3061
General References
  1. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Article]
  2. Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E: A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000 Sep;6(9):991-7. [Article]
  3. Olafsdottir BR, Rye DB, Scammell TE, Matheson JK, Stefansson K, Gulcher JR: Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. Neurology. 2001 Nov 27;57(10):1896-9. [Article]
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  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
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  8. Willie JT, Chemelli RM, Sinton CM, Yanagisawa M: To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci. 2001;24:429-58. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Suvorexantapproved, investigationalyestargetantagonistDetails
Lemborexantapproved, investigationalyestargetantagonistDetails
DaridorexantapprovedyestargetantagonistDetails
AlmorexantinvestigationalyestargetantagonistDetails
SB-649868investigationalyestargetantagonistDetails