Orexin/Hypocretin receptor type 1

BE0005864ProteinHumansHCRTR1

G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin (PubMed:32669442, PubMed:9491897). It is acted on by 9 drugs in DrugBank.

Gene name
HCRTR1
UniProtKB entry
O43613Swiss-Prot
Cellular location
Cell membrane
Residues / weight
425 residues · 47,535 Da
Also known as
Hypocretin receptor type 1 · Orexin receptor type 1 · ORXR1 · Ox-1-R · Ox1-R

Resolves to

Protein
UniProtO43613UniProt nameOX1R_HUMAN
Gene
HGNCHGNC:4848NCBI Gene3061GeneCardsHCRTR1
Pharmacology
IUPHAR/GtoPdb321KEGGhsa:3061
Structure
PDB4ZJ8PDB4ZJCPDB6TO7
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Orexin/Hypocretin receptor type 1, how selective are they, and which programs against it are still in active trials?

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