Vornorexant

DB21483ExperimentalSmall molecule

Vornorexant is a small molecule drug. The usage of the INN stem '-orexant' in the name indicates that Vornorexant is a orexin receptor antagonist. Vornorexant has a monoisotopic molecular weight...

Mechanism: Pharmacologically active on Orexin/Hypocretin receptor type 1 and Orexin receptor type 2
Curator reviewed
Formula / weight: C₂₃H₂₂FN₇O₂ · 447.474 g/mol (avg)
Code names: ORN-0829

Resolves to

Compound

UNIIZY54BP1CK3CAS2265899-49-6ChEMBLCHEMBL4638046

Structure

InChIKeyAEZZJXJIJFSUEM-QFIPXVFZSA-NSMILESCC1=CC(C(=O)N2CCCO[C@H]2CN2C=CC(=N2)C2=CC=C(F)C=N2)=C(C=C1)N1N=CC=N1

Targets

O43613HCRTR1O43614HCRTR2

What you can answer from here — as of August 31, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Vornorexant, and which of those have an active Phase 3 trial?

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