Diacylglycerol O-acyltransferase 2

BE0008719ProteinHumansDGAT2

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. It is acted on by 6 drugs in DrugBank.

Gene name
DGAT2
UniProtKB entry
Q96PD7Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
388 residues · 43,830 Da
Also known as
2.3.1.20 · Acyl-CoA retinol O-fatty-acyltransferase · ARAT · Diglyceride acyltransferase 2 · Retinol O-fatty-acyltransferase

Resolves to

Protein
UniProtQ96PD7UniProt nameDGAT2_HUMAN
Gene
HGNCHGNC:16940NCBI Gene84649GeneCardsDGAT2
Pharmacology
IUPHAR/GtoPdb3211KEGGhsa:84649
Drugs

What you can answer from here — as of September 03, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
24GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
17+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Diacylglycerol O-acyltransferase 2, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In