Protein S100-A8

BE0008955ProteinHumansS100A8

S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It is acted on by 6 drugs in DrugBank.

Gene name
S100A8
UniProtKB entry
P05109Swiss-Prot
Cellular location
Secreted
Residues / weight
93 residues · 10,834 Da
Also known as
CAGA · Calgranulin-A · Calprotectin L1L subunit · CFAG · Cystic fibrosis antigen

Resolves to

Protein
UniProtP05109UniProt nameS10A8_HUMAN
Gene
HGNCHGNC:10498NCBI Gene6279GeneCardsS100A8
Pharmacology
KEGGhsa:6279
Structure
PDB1MR8PDB1XK4PDB4GGF
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein S100-A8, how selective are they, and which programs against it are still in active trials?

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