Integrin alpha-5

BE0008988ProteinHumansITGA5

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It is acted on by 5 drugs in DrugBank.

Gene name
ITGA5
UniProtKB entry
P08648Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,049 residues · 114,536 Da
Also known as
CD49 antigen-like family member E · Fibronectin receptor subunit alpha · FNRA · Integrin alpha-F · VLA-5

Resolves to

Protein
UniProtP08648UniProt nameITA5_HUMAN
Gene
HGNCHGNC:6141NCBI Gene3678GeneCardsITGA5
Pharmacology
IUPHAR/GtoPdb2444KEGGhsa:3678
Structure
PDB3VI3PDB3VI4PDB4WJK
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Integrin alpha-5, how selective are they, and which programs against it are still in active trials?

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