Frataxin, mitochondrial

BE0008991ProteinHumansFXN

Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly (PubMed:12785837, PubMed:24971490). It is acted on by 7 drugs in DrugBank.

Gene name
FXN
UniProtKB entry
Q16595Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
210 residues · 23,135 Da
Also known as
1.16.3.1 · FRDA · Friedreich ataxia protein · Fxn · X25

Resolves to

Protein
UniProtQ16595UniProt nameFRDA_HUMAN
Gene
HGNCHGNC:3951NCBI Gene2395GeneCardsFXN
Pharmacology
KEGGhsa:2395
Structure
PDB1EKGPDB1LY7PDB3S4M
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Frataxin, mitochondrial, how selective are they, and which programs against it are still in active trials?

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