Huntingtin

BE0008995ProteinHumansHTT

May play a role in microtubule-mediated transport or vesicle function. It is acted on by 4 drugs in DrugBank.

Gene name
HTT
UniProtKB entry
P42858Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
3,142 residues · 347,600 Da
Also known as
HD · HD protein · Huntington disease protein · IT15

Resolves to

Protein
UniProtP42858UniProt nameHD_HUMAN
Gene
HGNCHGNC:4851NCBI Gene3064GeneCardsHTT
Pharmacology
KEGGhsa:3064
Structure
PDB2LD0PDB2LD2PDB3IO4
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Huntingtin, how selective are they, and which programs against it are still in active trials?

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