Calcitonin gene-related peptide type 1 receptor

BE0009009ProteinHumansCALCRL

G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). It is acted on by 14 drugs in DrugBank.

Gene name
CALCRL
UniProtKB entry
Q16602Swiss-Prot
Cellular location
Cell membrane
Residues / weight
461 residues · 52,978 Da
Also known as
Calcitonin receptor-like receptor · CGRP type 1 receptor · CGRPR · CRLR

Resolves to

Protein
UniProtQ16602UniProt nameCALRL_HUMAN
Gene
HGNCHGNC:16709NCBI Gene10203GeneCardsCALCRL
Pharmacology
IUPHAR/GtoPdb47KEGGhsa:10203
Structure
PDB3AQFPDB3N7PPDB3N7R
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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57+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcitonin gene-related peptide type 1 receptor, how selective are they, and which programs against it are still in active trials?

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