A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the... The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue.
- Mechanism
- Curator reviewed
While current drugs for treating HF and MI have a single mechanism of action, CGRP appears to work on several levels: for example, it (1) increases local blood flow enhancing hemodynamic proficiency; (2) protects heart muscle cells from the damage due to lack of oxygen (ischemia); and, (3) modulates the immune system by boosting anti-inflammatory cytokine expression while suppressing pro-inflammatory cytokines, which reduces the inflammatory response to provide a cardioprotective effect. All these actions are meant to minimize heart muscle damage and subsequent scar tissue formation, while promoting the healing process.
- Primary indication
- Investigated for use/treatment in myocardial infarction, heart disease, and asthma.Curator reviewed
- Also known as
- Calcitonin gene related peptide · Calcitonin-gene related peptide · Calcitonin-gene-related peptide · CGRP · LAB CGRP
Resolves to
What you can answer from here — as of July 03, 2026
Which drugs share a target with Calcitonin gene-related peptide, and which of those have an active Phase 3 trial?
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