Flap endonuclease 1

BE0009013ProteinHumansFEN1

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. It is acted on by 6 drugs in DrugBank.

Gene name
FEN1
UniProtKB entry
P39748Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
380 residues · 42,593 Da
Also known as
3.1.-.- · DNase IV · FEN-1 · Flap structure-specific endonuclease 1 · hFEN-1

Resolves to

Protein
UniProtP39748UniProt nameFEN1_HUMAN
Gene
HGNCHGNC:3650NCBI Gene2237GeneCardsFEN1
Pharmacology
KEGGhsa:2237
Structure
PDB1U7BPDB1UL1PDB3Q8K
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Flap endonuclease 1, how selective are they, and which programs against it are still in active trials?

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