Keratin, type II cytoskeletal 1

BE0009061ProteinHumansKRT1

Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. It is acted on by 3 drugs in DrugBank.

Gene name
KRT1
UniProtKB entry
P04264Swiss-Prot
Cellular location
Cell membrane
Residues / weight
644 residues · 66,039 Da
Also known as
67 kDa cytokeratin · CK-1 · Cytokeratin-1 · Hair alpha protein · K1

Resolves to

Protein
UniProtP04264UniProt nameK2C1_HUMAN
Gene
HGNCHGNC:6412NCBI Gene3848GeneCardsKRT1
Pharmacology
KEGGhsa:3848
Structure
PDB4ZRYPDB6E2JPDB6UUI
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Keratin, type II cytoskeletal 1, how selective are they, and which programs against it are still in active trials?

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