Coagulation factor XIII B chain

BE0009075ProteinHumansF13B

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. It is acted on by 5 drugs in DrugBank.

Gene name
F13B
UniProtKB entry
P05160Swiss-Prot
Cellular location
Secreted
Residues / weight
661 residues · 75,510 Da
Also known as
Fibrin-stabilizing factor B subunit · Protein-glutamine gamma-glutamyltransferase B chain · Transglutaminase B chain

Resolves to

Protein
UniProtP05160UniProt nameF13B_HUMAN
Gene
HGNCHGNC:3534NCBI Gene2165GeneCardsF13B
Pharmacology
KEGGhsa:2165
Structure
PDB8CMTPDB8CMU
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Coagulation factor XIII B chain, how selective are they, and which programs against it are still in active trials?

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