Inter-alpha-trypsin inhibitor heavy chain H1

BE0009080ProteinHumansITIH1

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of... It is acted on by 5 drugs in DrugBank.

Gene name
ITIH1
UniProtKB entry
P19827Swiss-Prot
Cellular location
Secreted
Residues / weight
911 residues · 101,388 Da
Also known as
IGHEP1 · Inter-alpha-inhibitor heavy chain 1 · Inter-alpha-trypsin inhibitor complex component III · ITI heavy chain H1 · ITI-HC1

Resolves to

Protein
UniProtP19827UniProt nameITIH1_HUMAN
Gene
HGNCHGNC:6166NCBI Gene3697GeneCardsITIH1
Pharmacology
KEGGhsa:3697
Structure
PDB6FPYPDB6FPZ
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inter-alpha-trypsin inhibitor heavy chain H1, how selective are they, and which programs against it are still in active trials?

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