Alpha-1-antichymotrypsin

BE0009090ProteinHumansSERPINA3

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. It is acted on by 5 drugs in DrugBank.

Gene name
SERPINA3
UniProtKB entry
P01011Swiss-Prot
Cellular location
Secreted
Residues / weight
423 residues · 47,650 Da
Also known as
AACT · ACT · Cell growth-inhibiting gene 24/25 protein · Serpin A3

Resolves to

Protein
UniProtP01011UniProt nameAACT_HUMAN
Gene
HGNCHGNC:16NCBI Gene12GeneCardsSERPINA3
Pharmacology
KEGGhsa:12
Structure
PDB1AS4PDB1QMNPDB2ACH
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-1-antichymotrypsin, how selective are they, and which programs against it are still in active trials?

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