Nucleophosmin

BE0009103ProteinHumansNPM1

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. It is acted on by 2 drugs in DrugBank.

Gene name
NPM1
UniProtKB entry
P06748Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
294 residues · 32,575 Da
Also known as
NPM · Nucleolar phosphoprotein B23 · Nucleolar protein NO38 · Numatrin

Resolves to

Protein
UniProtP06748UniProt nameNPM_HUMAN
Gene
HGNCHGNC:7910NCBI Gene4869GeneCardsNPM1
Pharmacology
KEGGhsa:4869
Structure
PDB2LLHPDB2P1BPDB2VXD
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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23Clinical trialsTrials of drugs acting on it, by phase and status
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36GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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75+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nucleophosmin, how selective are they, and which programs against it are still in active trials?

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