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CIGB 300

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Identification

Generic Name
CIGB 300
DrugBank Accession Number
DB16464
Background

CIGB-300, is under investigation in clinical trials for its potential to treat various conditions, including NCT01639638 (recurrent and nonrecurrent condyloma) and NCT01639625 (squamous cell carcinoma and adenocarcinoma of the cervix)

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Peptides
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • P15-Tat
External IDs
  • CIGB 300
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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action

CIGB 300 is a peptide that inhibits protein casein kinase 2 (CK2) activity. It binds to the phospho-acceptors of CK2 substrates, preventing their phosphorylation by CK2. It is currently being investigated as an anti-cancer drug as CK2 is overexpressed in numerous cancers.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
X6HMT2EDH9
CAS number
1072877-99-6

References

General References
  1. Benavent Acero F, Capobianco CS, Garona J, Cirigliano SM, Perera Y, Urtreger AJ, Perea SE, Alonso DF, Farina HG: CIGB-300, an anti-CK2 peptide, inhibits angiogenesis, tumor cell invasion and metastasis in lung cancer models. Lung Cancer. 2017 May;107:14-21. doi: 10.1016/j.lungcan.2016.05.026. Epub 2016 Jun 1. [Article]
  2. Perea SE, Baladron I, Valenzuela C, Perera Y: CIGB-300: A peptide-based drug that impairs the Protein Kinase CK2-mediated phosphorylation. Semin Oncol. 2018 Jan;45(1-2):58-67. doi: 10.1053/j.seminoncol.2018.04.006. Epub 2018 May 3. [Article]
  3. Sarduy MR, Garcia I, Coca MA, Perera A, Torres LA, Valenzuela CM, Baladron I, Solares M, Reyes V, Hernandez I, Perera Y, Martinez YM, Molina L, Gonzalez YM, Ancizar JA, Prats A, Gonzalez L, Casaco CA, Acevedo BE, Lopez-Saura PA, Alonso DF, Gomez R, Perea-Rodriguez SE: Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer. Br J Cancer. 2015 May 12;112(10):1636-43. doi: 10.1038/bjc.2015.137. Epub 2015 Apr 16. [Article]
Not Available

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2CompletedNot AvailableCervical Adenocarcinoma / Cervical Squamous Cell Carcinoma1somestatusstop reasonjust information to hide
2, 3TerminatedTreatmentNonrecurrent Condyloma / Recurrent Condyloma1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at January 21, 2021 01:43 / Updated at July 23, 2024 18:02