Dihydrofolate reductase

Details

Name
Dihydrofolate reductase
Kind
protein
Synonyms
  • 1.5.1.3
Gene Name
dfrB
UniProtKB Entry
A0A0M3KKX1TrEMBL
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
NCBI Taxonomy ID
273036
Amino acid sequence
>lcl|BSEQ0051086|Dihydrofolate reductase
TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNV
VLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGD
TFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK
Number of residues
157
Molecular Weight
17991.48
Theoretical pI
Not Available
GO Classification
Functions
dihydrofolate reductase activity / NADP binding
Processes
glycine biosynthetic process / nucleotide biosynthetic process / one-carbon metabolic process / tetrahydrofolate biosynthetic process
General Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Specific Function
dihydrofolate reductase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDA0A0M3KKX1
UniProtKB Entry NameA0A0M3KKX1_STAAB
PDB ID(s)4TU5
General References
  1. Keshipeddy S, Reeve SM, Anderson AC, Wright DL: Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus. J Am Chem Soc. 2015 Jul 22;137(28):8983-90. doi: 10.1021/jacs.5b01442. Epub 2015 Jul 8. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
5-[(3S)-3-(2-methoxybiphenyl-4-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineexperimentalunknowntargetDetails
5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineexperimentalunknowntargetDetails
5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineexperimentalunknowntargetDetails
6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamineexperimentalunknowntargetDetails
5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamineexperimentalunknowntargetDetails