Sodium- and chloride-dependent taurine transporter

BE0009148ProteinHumansSLC6A6

Mediates sodium- and chloride-dependent transport of taurine, a key amino acid (PubMed:31345061, PubMed:31903486, PubMed:39837997, PubMed:40108165, PubMed:40108449, PubMed:40615403, PubMed:40789850, PubMed:41269860, PubMed:41652173, PubMed:8010975, PubMed:8382624, PubMed:8654117). It is acted on by 2 drugs in DrugBank.

Gene name
SLC6A6
UniProtKB entry
P31641Swiss-Prot
Cellular location
Cell membrane
Residues / weight
620 residues · 69,829 Da
Also known as
Solute carrier family 6 member 6 · Taurine transporter · TauT

Resolves to

Protein
UniProtP31641UniProt nameSC6A6_HUMAN
Gene
HGNCHGNC:11052NCBI Gene6533GeneCardsSLC6A6
Pharmacology
KEGGhsa:6533
Structure
PDB9J7MPDB9J7NPDB9J7O
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium- and chloride-dependent taurine transporter, how selective are they, and which programs against it are still in active trials?

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