Retinoid isomerohydrolase

BE0009149ProteinHumansRPE65

Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. It is acted on by 4 drugs in DrugBank.

Gene name
RPE65
UniProtKB entry
Q16518Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
533 residues · 60,947 Da
Also known as
3.1.1.64 · All-trans-retinyl-palmitate hydrolase · Lutein isomerase · Meso-zeaxanthin isomerase · Retinal pigment epithelium-specific 65 kDa protein

Resolves to

Protein
UniProtQ16518UniProt nameRPE65_HUMAN
Gene
HGNCHGNC:10294NCBI Gene6121GeneCardsRPE65
Pharmacology
KEGGhsa:6121
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Retinoid isomerohydrolase, how selective are they, and which programs against it are still in active trials?

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