Bone morphogenetic protein receptor type-1A

BE0009272ProteinHumansBMPR1A

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. It is acted on by 4 drugs in DrugBank.

Gene name
BMPR1A
UniProtKB entry
P36894Swiss-Prot
Cellular location
Cell membrane
Residues / weight
532 residues · 60,197 Da
Also known as
2.7.11.30 · Activin receptor-like kinase 3 · ACVRLK3 · ALK-3 · ALK3

Resolves to

Protein
UniProtP36894UniProt nameBMR1A_HUMAN
Gene
HGNCHGNC:1076NCBI Gene657GeneCardsBMPR1A
Pharmacology
IUPHAR/GtoPdb1786KEGGhsa:657
Structure
PDB1ES7PDB1REWPDB2GOO
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bone morphogenetic protein receptor type-1A, how selective are they, and which programs against it are still in active trials?

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