Iduronate 2-sulfatase

BE0009328ProteinHumansIDS

Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. It is acted on by 4 drugs in DrugBank.

Gene name
IDS
UniProtKB entry
P22304Swiss-Prot
Cellular location
Lysosome
Residues / weight
550 residues · 61,872 Da
Also known as
3.1.6.13 · Alpha-L-iduronate sulfate sulfatase · Idursulfase · SIDS

Resolves to

Protein
UniProtP22304UniProt nameIDS_HUMAN
Gene
HGNCHGNC:5389NCBI Gene3423GeneCardsIDS
Pharmacology
KEGGhsa:3423
Structure
PDB5FQLPDB6IOZ
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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51+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Iduronate 2-sulfatase, how selective are they, and which programs against it are still in active trials?

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