Sodium/iodide cotransporter

BE0009346ProteinHumansSLC5A5

Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:20797386, PubMed:31310151, PubMed:32084174, PubMed:8806637, PubMed:9329364). It is acted on by 7 drugs in DrugBank.

Gene name
SLC5A5
UniProtKB entry
Q92911Swiss-Prot
Cellular location
Cell membrane
Residues / weight
643 residues · 68,666 Da
Also known as
Na(+)/I(-) cotransporter · Na(+)/I(-) symporter · Natrium iodide transporter · NIS · Sodium-iodide symporter

Resolves to

Protein
UniProtQ92911UniProt nameSC5A5_HUMAN
Gene
HGNCHGNC:11040NCBI Gene6528GeneCardsSLC5A5
Pharmacology
KEGGhsa:6528
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/iodide cotransporter, how selective are they, and which programs against it are still in active trials?

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