Botulinum neurotoxin type D

BE0009354ProteinClostridium botulinumbotD

Botulinum neurotoxin type D Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory... It is acted on by 1 drug in DrugBank.

Gene name
botD
UniProtKB entry
P19321Swiss-Prot
Cellular location
Secreted
Residues / weight
1,276 residues · 146,871 Da
Also known as
3.4.24.69 · BoNT/D · Bontoxilysin-D

Resolves to

Protein
UniProtP19321UniProt nameBXD_CBDP
Structure
PDB2FPQPDB3N7JPDB3OBR
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Botulinum neurotoxin type D, how selective are they, and which programs against it are still in active trials?

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