Bone morphogenetic protein receptor type-1B

BE0009415ProteinHumansBMPR1B

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. It is acted on by 4 drugs in DrugBank.

Gene name
BMPR1B
UniProtKB entry
O00238Swiss-Prot
Cellular location
Cell membrane
Residues / weight
502 residues · 56,930 Da
Also known as
2.7.11.30 · BMP type-1B receptor · BMPR-1B

Resolves to

Protein
UniProtO00238UniProt nameBMR1B_HUMAN
Gene
HGNCHGNC:1077NCBI Gene658GeneCardsBMPR1B
Pharmacology
IUPHAR/GtoPdb1789KEGGhsa:658
Structure
PDB3MDY
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bone morphogenetic protein receptor type-1B, how selective are they, and which programs against it are still in active trials?

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