Glycogen synthase kinase-3 alpha

BE0009446ProteinHumansGSK3A

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2),... It is acted on by 9 drugs in DrugBank.

Gene name
GSK3A
UniProtKB entry
P49840Swiss-Prot
Residues / weight
483 residues · 50,980 Da
Also known as
2.7.11.26 · GSK-3 alpha · Serine/threonine-protein kinase GSK3A

Resolves to

Protein
UniProtP49840UniProt nameGSK3A_HUMAN
Gene
HGNCHGNC:4616NCBI Gene2931GeneCardsGSK3A
Pharmacology
IUPHAR/GtoPdb2029KEGGhsa:2931
Structure
PDB7SXFPDB7SXG
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycogen synthase kinase-3 alpha, how selective are they, and which programs against it are still in active trials?

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