LIM domain kinase 2

BE0009456ProteinHumansLIMK2

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). It is acted on by 3 drugs in DrugBank.

Gene name
LIMK2
UniProtKB entry
P53671Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, spindle
Residues / weight
638 residues · 72,231 Da
Also known as
2.7.11.1 · LIMK-2

Resolves to

Protein
UniProtP53671UniProt nameLIMK2_HUMAN
Gene
HGNCHGNC:6614NCBI Gene3985GeneCardsLIMK2
Pharmacology
IUPHAR/GtoPdb2055KEGGhsa:3985
Structure
PDB1X6APDB4TPTPDB5NXD
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on LIM domain kinase 2, how selective are they, and which programs against it are still in active trials?

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