Mitogen-activated protein kinase kinase kinase 12

BE0009464ProteinHumansMAP3K12

Part of a non-canonical MAPK signaling pathway (PubMed:28111074). It is acted on by 3 drugs in DrugBank.

Gene name
MAP3K12
UniProtKB entry
Q12852Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
859 residues · 93,218 Da
Also known as
2.7.11.25 · DLK · Dual leucine zipper bearing kinase · Leucine-zipper protein kinase · MAPK-upstream kinase

Resolves to

Protein
UniProtQ12852UniProt nameM3K12_HUMAN
Gene
HGNCHGNC:6851NCBI Gene7786GeneCardsMAP3K12
Pharmacology
IUPHAR/GtoPdb2072KEGGhsa:7786
Structure
PDB5CENPDB5CEOPDB5CEP
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 12, how selective are they, and which programs against it are still in active trials?

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