GDC-0134

DB17079InvestigationalSmall molecule

GDC-0134: Overview.

Mechanism: Pharmacologically active on Mitogen-activated protein kinase kinase kinase 12
Curator reviewed
Formula / weight: C₁₉H₂₀F₄N₆O₂ · 440.403 g/mol (avg)
Also known as: 2-pyridinamine, 3-(difluoromethoxy)-5-(2-(3,3-difluoro-1-pyrrolidinyl)-6-(1s,4s)-2-oxa-5-azabicyclo(2.2.1)hept-5-yl-4-pyrimidinyl)-
Code names: GDC-0134 · RG-6000

Resolves to

Compound

Structure

InChIKeySKMKJBYBPYBDMN-RYUDHWBXSA-NSMILESNC1=NC=C(C=C1OC(F)F)C1=CC(=NC(=N1)N1CCC(F)(F)C1)N1C[C@@H]2C[C@H]1CO2

Targets

What you can answer from here — as of July 08, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with GDC-0134, and which of those have an active Phase 3 trial?

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