MAP kinase-interacting serine/threonine-protein kinase 2

BE0009489ProteinHumansMKNK2

Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. It is acted on by 3 drugs in DrugBank.

Gene name
MKNK2
UniProtKB entry
Q9HBH9Swiss-Prot
Cellular location
Nucleus, PML body
Residues / weight
465 residues · 51,874 Da
Also known as
2.7.11.1 · GPRK7 · MAP kinase signal-integrating kinase 2 · MAPK signal-integrating kinase 2 · MNK2

Resolves to

Protein
UniProtQ9HBH9UniProt nameMKNK2_HUMAN
Gene
HGNCHGNC:7111NCBI Gene2872GeneCardsMKNK2
Pharmacology
IUPHAR/GtoPdb2105KEGGhsa:2872
Structure
PDB2AC3PDB2AC5PDB2HW7
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on MAP kinase-interacting serine/threonine-protein kinase 2, how selective are they, and which programs against it are still in active trials?

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