Myosin light chain kinase, smooth muscle

BE0009492ProteinHumansMYLK

Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC) (PubMed:11113114). It is acted on by 5 drugs in DrugBank.

Gene name
MYLK
UniProtKB entry
Q15746Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,914 residues · 210,713 Da
Also known as
2.7.11.18 · Kinase-related protein · KRP · MLCK · MLCK1

Resolves to

Protein
UniProtQ15746UniProt nameMYLK_HUMAN
Gene
HGNCHGNC:7590NCBI Gene4638GeneCardsMYLK
Pharmacology
IUPHAR/GtoPdb1552KEGGhsa:4638
Structure
PDB2CQVPDB2K0FPDB2YR3
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
18GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
44+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Myosin light chain kinase, smooth muscle, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In