Serine/threonine-protein kinase PAK 2

BE0009506ProteinHumansPAK2

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). It is acted on by 3 drugs in DrugBank.

Gene name
PAK2
UniProtKB entry
Q13177Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
524 residues · 58,042 Da
Also known as
2.7.11.1 · Gamma-PAK · p21-activated kinase 2 · p58 · PAK-2

Resolves to

Protein
UniProtQ13177UniProt namePAK2_HUMAN
Gene
HGNCHGNC:8591NCBI Gene5062GeneCardsPAK2
Pharmacology
IUPHAR/GtoPdb2134KEGGhsa:5062
Structure
PDB3PCSPDB9D51PDB9LBF
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase PAK 2, how selective are they, and which programs against it are still in active trials?

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