Serine/threonine-protein kinase PAK 3

BE0009507ProteinHumansPAK3

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. It is acted on by 3 drugs in DrugBank.

Gene name
PAK3
UniProtKB entry
O75914Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
559 residues · 62,309 Da
Also known as
2.7.11.1 · Beta-PAK · Oligophrenin-3 · OPHN3 · p21-activated kinase 3

Resolves to

Protein
UniProtO75914UniProt namePAK3_HUMAN
Gene
HGNCHGNC:8592NCBI Gene5063GeneCardsPAK3
Pharmacology
IUPHAR/GtoPdb2135KEGGhsa:5063
Structure
PDB6FD3
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase PAK 3, how selective are they, and which programs against it are still in active trials?

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