Serine/threonine-protein kinase D1

BE0009525ProteinHumansPRKD1

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B... It is acted on by 2 drugs in DrugBank.

Gene name
PRKD1
UniProtKB entry
Q15139Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
912 residues · 101,703 Da
Also known as
2.7.11.13 · nPKC-D1 · nPKC-mu · PKD · PKD1

Resolves to

Protein
UniProtQ15139UniProt nameKPCD1_HUMAN
Gene
HGNCHGNC:9407NCBI Gene5587GeneCardsPRKD1
Pharmacology
IUPHAR/GtoPdb1489KEGGhsa:5587
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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33GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase D1, how selective are they, and which programs against it are still in active trials?

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