Proto-oncogene tyrosine-protein kinase ROS

BE0009534ProteinHumansROS1

Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. It is acted on by 11 drugs in DrugBank.

Gene name
ROS1
UniProtKB entry
P08922Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,347 residues · 263,913 Da
Also known as
2.7.10.1 · c-Ros receptor tyrosine kinase · MCF3 · Proto-oncogene c-Ros · Proto-oncogene c-Ros-1

Resolves to

Protein
UniProtP08922UniProt nameROS1_HUMAN
Gene
HGNCHGNC:10261NCBI Gene6098GeneCardsROS1
Pharmacology
IUPHAR/GtoPdb1840KEGGhsa:6098
Structure
PDB3ZBFPDB4UXLPDB7Z5W
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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28Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proto-oncogene tyrosine-protein kinase ROS, how selective are they, and which programs against it are still in active trials?

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