This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- taletrectinib
- DrugBank Accession Number
- DB18711
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for taletrectinib (DB18711)
- Weight
- Average: 551.619
Monoisotopic: 551.254397378 - Chemical Formula
- C29H34FN5O5
- Synonyms
- Taletrectinib adipate
- External IDs
- DS-6051B
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 6KLL51GNBG
- CAS number
- 1505515-69-4
- InChI Key
- DORJQZDOULKINH-QNBGGDODSA-N
- InChI
- InChI=1S/C23H24FN5O.C6H10O4/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18;7-5(8)3-1-2-4-6(9)10/h3-13,15-16H,14,25H2,1-2H3,(H,27,28);1-4H2,(H,7,8)(H,9,10)/t15-,16-;/m1./s1
- IUPAC Name
- 3-{4-[(2R)-2-aminopropoxy]phenyl}-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine; hexanedioic acid
- SMILES
- OC(=O)CCCCC(O)=O.C[C@@H](N)COC1=CC=C(C=C1)C1=CN=C2C=CC(N[C@H](C)C3=CC=CC(F)=C3)=NN12
References
- General References
- Not Available
- External Links
- ChemSpider
- 88297530
- ChEMBL
- CHEMBL4650361
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Active Not Recruiting Treatment Non-Small Cell Lung Cancer (NSCLC) 1 2 Not Yet Recruiting Treatment Breast Cancer / Metastatic Breast Cancer 1 2 Recruiting Treatment Non-Small Cell Lung Cancer (NSCLC) 1 1 Completed Treatment Advanced Malignant Solid Tumor 1 1 Completed Treatment Solid Tumors 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 4.03 Chemaxon pKa (Strongest Acidic) 17.72 Chemaxon pKa (Strongest Basic) 9.37 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 77.47 Å2 Chemaxon Rotatable Bond Count 12 Chemaxon Refractivity 127.37 m3·mol-1 Chemaxon Polarizability 43.79 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 21, 2023 22:21 / Updated at December 22, 2023 19:51