Inward rectifier potassium channel 2

BE0009710ProteinHumansKCNJ2

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:36149965, PubMed:7590287, PubMed:9490857). It is acted on by 6 drugs in DrugBank.

Gene name
KCNJ2
UniProtKB entry
P63252Swiss-Prot
Cellular location
Cell membrane
Residues / weight
427 residues · 48,288 Da
Also known as
Cardiac inward rectifier potassium channel · hIRK1 · Inward rectifier K(+) channel Kir2.1 · IRK-1 · IRK1

Resolves to

Protein
UniProtP63252UniProt nameKCNJ2_HUMAN
Gene
HGNCHGNC:6263NCBI Gene3759GeneCardsKCNJ2
Pharmacology
KEGGhsa:3759
Structure
PDB6SPZPDB7ZDZPDB8QQL
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
25+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Inward rectifier potassium channel 2, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In